期刊
NATURE CELL BIOLOGY
卷 8, 期 12, 页码 1376-U34出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1503
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- Telethon [GGP04235] Funding Source: Medline
Brefeldin- A ADP- ribosylated substrate (BARS) and dynamin function in membrane fission in distinct intracellular transport pathways(1), but whether their functions are mechanistically similar is unclear. Here, we show that ARFGAP1, a GTPase-activating protein (GAP) for ADP- ribosylation factor 1 (ARF1)(2), couples to either BARS or endophilin B for vesicle formation by the coat protein I (COPI) complex- a finding that reveals an unanticipated mechanistic flexibility in mammalian COPI transport. Because dynamin is coupled to endophilin A in vesicle formation by the clathrin- coat complex(3-5), our finding also predicts that dynamin and ARF GAPs are likely to be functional counterparts in membrane fission among different transport pathways that connect intracellular membrane compartments.
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