期刊
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 72, 期 1-2, 页码 85-93出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2005.02.004
关键词
endometriosis; animal model; P38 MAP kinase; IL-6; MCP-1; peritoneal fluid
In various cells including endometriotic cells, p38 mitogen-activated protein kinase (MAPK) plays essential roles for inflammation, an etiological factor for endometriosis. We evaluated the effect of FR 167653, a p38 MAPK inhibitor, on the development of endometriosis using a murine model. As an endometriosis model, estradiol-treated ovariectornized BALB/c mice were injected intraperitoneally with endometrial fragments of the syngenic donor mice. The animals were injected with either 30 mg/kg FR 167653 or only vehicle (control) s.c. twice a day, starting 2 days before endometrial injection. Three weeks later, the peritoneal fluids and the developed endometriotic lesions were collected. Both the weight of all the endometriotic lesions per mouse and the concentrations of interleukin-6 and monocyte chemoattractant protein-1 in the peritoneal fluid were significantly lower in the FR 167653-treated mice than in the control mice. These findings suggest that FR 167653 may inhibit the development of endometriosis possibly by suppressing peritoneal inflammatory status. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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