期刊
JOURNAL OF CLINICAL VIROLOGY
卷 37, 期 -, 页码 S52-S56出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1386-6532(06)70012-9
关键词
human herpesvirus 6; congenital infection; seizure; encephalitis; transplantation
类别
Human herpesvirus 6 infects virtually all children within the first few years of life and like other herpesviruses, establishes latency after primary infection. In immunocompromised hosts, especially hematopoietic cell transplant (HCT) recipients, HHV-6 has been demonstrated to reactivate frequently. This reactivation has been associated with a number of different clinical endpoints in HCT recipients, including central nervous system (CNS) disease. There have been many detailed descriptions of individual patients with HHV-6-associated encephalitis. In addition, longitudinal observational studies have established a correlation between systemic HHV-6 reactivation and CNS dysfunction. Further research is needed to define optimal diagnostic, prevention, and treatment strategies. (c) 2006 Elsevier B.V. All rights reserved.
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