期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 103, 期 49, 页码 18680-18684出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0609030103
关键词
oncogene; retroviral mutagenesis
资金
- NCI NIH HHS [R01 CA100266, CA 100266] Funding Source: Medline
- NIAID NIH HHS [AI 39506, R01 AI039506] Funding Source: Medline
- NIA NIH HHS [AG 20684, R01 AG020684] Funding Source: Medline
Retroviruses can cause tumors when they integrate near a protooncogene or tumor suppressor gene of the host. We infected > 2,500 mice with the SL3-3 murine leukemia virus; in 22 resulting tumors, we found provirus integrations nearby or within the gene that contains the mir-17-92 microRNA (miRNA) cistron. Using quantitative real-time PCR, we showed that expression of miRNA was increased in these tumors, indicating that retroviral infection can induce expression of oncogenic miRNAs. Our results demonstrate that retroviral mutagenesis can be a potent tool for miRNA discovery.
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