期刊
ORGANIC LETTERS
卷 8, 期 25, 页码 5785-5788出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol062423x
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资金
- NCI NIH HHS [R01 CA 88986] Funding Source: Medline
Although native chemical ligation (NCL) is emerging as a powerful method for the assembly of (glyco) peptide building blocks, its applicability is reduced when peptide segments are poorly soluble in aqueous buffer. We have found that incorporating reactants in liposomes allows NCL of lipophilic peptides and lipopeptides. Furthermore, the reaction rates of liposome-mediated NCL are higher than traditional reaction conditions resulting in improved yields.
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