期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 71, 期 25, 页码 9458-9463出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo061763t
关键词
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资金
- NIGMS NIH HHS [T32 GM008523] Funding Source: Medline
1,2,4-Trisubstituted cyclohexadienals can be prepared synthetically by self-condensation of beta-methyl substituted alpha,beta-unsaturated aldehydes. While molecules with this structural scaffold have been observed in nature, the biological roles of these compounds have yet to be thoroughly investigated. Here we investigate the use of L-proline and its derivatives to effect synthesis of these ring-fused homodimers. The scope of this reaction is investigated with different substrates and proline derivatives. Mechanistic hypotheses are put forth supported by NMR and mass spectrometry studies. The method will enable diversification of this scaffold in sufficient quantities for biological investigations.
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