期刊
FEBS LETTERS
卷 580, 期 28-29, 页码 6623-6628出版社
WILEY
DOI: 10.1016/j.febslet.2006.11.011
关键词
curcumin; tannic acid; catechin; PKC; calcium influx; caspase-3
Glutamate excitotoxicity is mediated by intracellular Ca2+ overload, caspase-3 activation, and ROS generation. Here, we show that curcumin, tannic acid (TA) and (+)-catechin hydrate (CA) all inhibited glutamate-induced excitotoxicity. Curcumin inhibited PKC activity, and subsequent phosphorylation of NR1 of the NMDA receptor. As a result, glutamate-mediated Ca2+ influx was reduced. TA attenuated glutamate-mediated Ca2+ influx only when simultaneously administered, directly interfering with Ca2+. Both curcumin and TA inhibited glutamate-induced caspase-3 activation. Although Ca2+ influx was not attenuated by CA, caspase-3 was reduced by direct inhibition of the enzyme. All polyphenols reduced glutamate-induced generation of ROS. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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