期刊
TETRAHEDRON LETTERS
卷 47, 期 50, 页码 8917-8920出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.10.056
关键词
pyrido[4,3-d]pyrimidines; heterocycles; combinatorial chemistry; library
The synthesis of a 5,7-dichloropyrido[4,3-d]pyrimidine scaffold is described. The chlorine at position 5 can selectively be displaced by different palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitutions. In the subsequent step, the chlorine at position 7 can be further derivatized. The described synthetic sequence allows for the construction of a diverse pyrido[4,3-d]pyrimidine library with structural variations at positions 5 and 7. (c) 2006 Elsevier Ltd. All rights reserved.
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