期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 12, 期 36, 页码 9228-9237出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200601043
关键词
acceleration; enantioselectivity; ionic liquids; lipids; transesterification
Several types of imidazolium salt ionic liquids were prepared derived from poly(oxyethylene)alkyl sulfate and used as an additive or coating material for lipase-catalyzed transesterification in an organic solvent. A remarkably increased enantioselectivity was obtained when the salt was added at 310 mol % versus substrate in the Burkholderia cepacia lipase (lipase PS-C)catalyzed transesterification of 1-phe-nylethanol by using vinyl acetate in diisopropyl ether or a hexane solvent system. In particular, a remarkable acceleration was accomplished by the ionic liquid coating with lipase PS in an iPr(2)O solvent system while maintaining excellent enantioselectivity; it reached approximately 500- to 1000-fold acceleration for some substrates with excellent enantioselectivity. A similar acceleration was also observed for IL1-coated Candida rugosa lipase. MALDI-TOF mass spectrometry experiments of the ionic-liquid-coated lipase PS suggest that ionic liquid binds with lipase protein.
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