期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 12, 期 36, 页码 9346-9352出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200600616
关键词
asymmetric synthesis; binaphthyls; boronic acids; enantioselectivity; Suzuki-Miyaura reaction
Naphthylboronic acids prepared as reported in the literature are contaminated with HCl A very simple purification prior to their use in Suzuki-Miyaura couplings has been found to be crucial, rendering efficient some reactions that had been reported in the literature either to fail or to give extremely poor yields. With this improvement, parent boronic acids can be used instead of esters at moderate temperatures, and bromo derivatives can be used instead of iodo derivatives. Convenient access to chiral sterically hindered binaphthalene derivatives has been achieved through the use of boronic acids, binaphthalenes, and ferrocenylphosphane ligands. The products were obtained in good yields (9555 %) and with good enantioselectivities (90-50 %). Bulkier ligands are less efficient in the coupling of hindered partners.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据