期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 12, 期 46, 页码 7463-7466出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v12.i46.7463
关键词
skeletal muscle; apoptosis; disuse atrophy; aging
资金
- NIAMS NIH HHS [AR47577, R01 AR047577] Funding Source: Medline
- NIA NIH HHS [AG20407] Funding Source: Medline
Apoptosis is necessary for maintaining the integrity of proliferative tissues, such as epithelial cells of the gastrointestinal system. The role of apoptosis in post mitotic tissues, such as skeletal muscle, is less well defined, Apoptosis during muscle atrophy occurs in both myonuclei and other muscle cell types. Apoptosis of myonuclei likely contributes to the loss of muscle mass, but the mechanisms underlying this process are largely unknown. Caspase-dependent as well as -independent pathways have been implicated and the mode by which atrophy is induced likely determines the apoptotic mechanisms that are utilized. It remains to be determined whether a decrease in apoptosis will alleviate atrophy and distinct research strategies may be required for different causes of skeletal muscle loss. (c) 2006 The WJG Press. All rights reserved.
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