期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 552, 期 1-3, 页码 159-161出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2006.09.012
关键词
melatonin; diadenosine tetraphosphate; dinucleotides; melatonin receptor; P2Y receptor; tear secretion
Diadenosine tetraphosphate (Ap(4)A, 0.03 nmol) applied topically to the cornea of New Zealand white rabbits, evoked an increase in tear secretion of 9.7 +/- 2.60% (N = 7). Melatonin (1 nmol) had no significant effect. Application of Ap(4)A in combination with melatonin, evoked a significantly greater increase in tear secretion of 34.2 +/- 5.8% (N = 11). This potentiating effect of melatonin was blocked by pretreating the cornea with a topical application of the melatonin receptor antagonist, luzindole (240 nmol). Melatonin combined with Ap(4)A may be useful for treating dry eye conditions. (c) 2006 Elsevier B.V. All rights reserved.
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