期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 24, 页码 6306-6309出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.09.012
关键词
triterpene; betulinic acid; inhibitors of nitric oxide production; RAW 264.7 cells; inducer of heme oxygenase-1
资金
- NCI NIH HHS [1 R01 CA78814, R01 CA078814] Funding Source: Medline
Fifteen new betulinic acid analogues were designed, synthesized, and tested for anti-inflammatory activity. Many of these analogues effectively suppress nitric oxide (NO) production in RAW cells stimulated with interferon-gamma. Analogue 10 is highly and orally active in vivo for induction of the anti-inflammatory and cytoprotective enzyme, heme oxygenase-1. (c) 2006 Elsevier Ltd. All rights reserved.
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