期刊
SCIENCE
卷 314, 期 5806, 页码 1780-1783出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1133690
关键词
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资金
- NIAID NIH HHS [F32AI60306, AI41014, AI059176, R01 AI021423, AI30230, AI36629, 1R01AI045806-01A1, AI05093, AI21423, R01 AI036629, R01 AI021423-20] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
The majority of known Toxoplasma gondii isolates from Europe and North America belong to three clonal lines that differ dramatically in their virulence, depending on the host. To identify the responsible genes, we mapped virulence in F-1 progeny derived from crosses between type II and type III strains, which we introduced into mice. Five virulence ( VIR) loci were thus identified, and for two of these, genetic complementation showed that a predicted protein kinase (ROP18 and ROP16, respectively) is the key molecule. Both are hypervariable rhoptry proteins that are secreted into the host cell upon invasion. These results suggest that secreted kinases unique to the Apicomplexa are crucial in the host-pathogen interaction.
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