期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 14, 期 24, 页码 8219-8248出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.09.019
关键词
alpha 7; nicotinic; nAChR; PHA-543613
A novel set of azabicyclic aryl amides have been identified as potent and selective agonists of the alpha 7 nAChR. A two-pronged approach was taken to improve the potential hERG liability of previously disclosed alpha 7 nAChR agonist, PNU-282,987, while maintaining the compound's other desirable pharmacological properties. The first approach involved further exploration of the aryl carboxylic acid fragment of PNU-282,987, while the second approach focused on modification of the azabicyclic amine portion of PNU-282,987. The best compounds from each series are characterized by rapid brain penetration, good oral bioavailability in rat, and demonstrate in vivo efficacy in a rat P50 auditory sensory gating assay. At least one analog from each series (1h, 1o, 2a, 9a, and 18a) shows an improved hERG safety profile over PNU-282,987. (c) 2006 Elsevier Ltd. All rights reserved.
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