FeCl3-catalyzed propargylation of aromatic compounds with propargylic acetates

A new method for the synthesis of propargylated aromatic compounds is developed. The reaction was carried out at room temperature in the presence of a catalytic amount of FeCl3 in acetonitrile, high product yields were obtained with excellent regioselectivity and the reaction proceeded smoothly without exclusion of moisture or air. (c) 2006 Elsevier Ltd. All rights reserved.