期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 103, 期 51, 页码 19436-19441出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0609515103
关键词
immunopathogenesis; Bcl-2; CD95
资金
- Intramural NIH HHS Funding Source: Medline
Perturbations of B cells in HIV-infected individuals are associated with the overrepresentation of distinct B cell populations. Here we describe high extrinsic CD95 ligand (CD95L)-mediated apoptosis in CD10(-)/CD21(lo) mature/activated B cells that likely arise from HIV-induced immune activation. In addition, high intrinsic apoptosis was observed in CD10(+) immature/transitional B cells that likely arise as a result of HIV-induced lymphopenia. CD10(+) B cells expressed low levels of Bcl-2 and Bcl-xL, consistent with their high susceptibility to intrinsic apoptosis. Higher levels of activated Bax and Bak were induced in CD10(+) B cells compared with CD95L-treated CD10(-) B cells, consistent with the greater involvement of mitochondria in intrinsic vs. extrinsic apoptosis. Of interest, both extrinsic apoptosis in CD95L-treated CD10(-) B cells and intrinsic apoptosis in CD10(+) B cells were associated with caspase-8 activation. Our data suggest that two distinct mechanisms of apoptosis are associated with B cells of HIV-infected individuals, and both may contribute to the depletion and dysfunction of B cells in these individuals.
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