期刊
FEBS LETTERS
卷 580, 期 30, 页码 6903-6908出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2006.11.055
关键词
ING4; PHD; histone binding; phosphoinositide binding; tumour suppressor; chromatin remodelling
Plant homeodomain (PHD) fingers are frequently present in proteins involved in chromatin remodelling, and some of them bind to histones. The family of proteins inhibitors of growth (ING) contains a PHD finger that bind to histone-3 trimethylated at lysine 4, and those of ING1 and ING2 also act as nuclear phosphoinositide receptors. We have determined the structure of ING4 PHD, and characterised its binding to phosphoinositides and histone methylated tails. In contrast to ING2, ING4 is not a phosphoinositide receptor and binds with similar affinity to the different methylation states of histone-3 at lysine 4. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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