期刊
TETRAHEDRON
卷 62, 期 52, 页码 12227-12236出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2006.10.014
关键词
1,3-dipolar cycloaddition; alpha-alkoxycarbonylnitrones; vinyl ethers; europium; stereoselective
Uncatalyzed cycloaddition of alpha-alkoxycarbonylnitrones 1 with vinyl ethers 7 gave mixtures of cis- and trans-cycloadducts 8, whereas Eu(fod)(3)-catalyzed cycloaddition of 1 with 7 gave the trans-cycloadducts trans-8 in a highly stereoselective manner. NMR studies indicated that Eu(fod)3 selectively activated (Z)-nitrones (Z)-1 in E,Z-equilibrium mixtures of nitrones 1. In contrast, the reaction of I with allyl alcohols 12 in the presence of Eu(fod)3 resulted in sequential transesterification and intramolecular cycloaddition to give intramolecular cycloadducts 13. (c) 2006 Elsevier Ltd. All rights reserved.
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