期刊
TETRAHEDRON LETTERS
卷 47, 期 52, 页码 9305-9308出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.10.102
关键词
TMC-69-6H; antitumor activity; PTP1B inhibitor; diastereoselective aldolization; metathesis
An efficient method for the synthesis of antitumor TMC-69-6H and related analogs which have been demonstrated to be phosphatase (PTP1B, VHR, and PP1) inhibitors, is reported. This strategy involves two key steps: a diastereoselective aldol reaction and a one-pot tandem ring-closing and cross metathesis for the construction of the pyran moiety. (c) 2006 Elsevier Ltd. All rights reserved.
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