Prognostic usefulness of some parameters in dogs with canine parvovirus

The purpose of this study was to evaluate the prognostic usefulness of some parameters in dogs with canine parvovirus (CPV). Fifty-nine animals which consist of 39 ill and 20 healthy puppies were used in the study. All puppies were underwent a complete physical examination and laboratory variables (CBC, serum routine biochemistry profile, cTn-I, TNF-alpha) on their first admission to clinic and on following every day before treatment until discharge or death. Despite aggressive treatment with available therapy, 14 of 39 dogs died. Non-survivor dogs had significantly lower leukocyte, lymphocyte, monocyte and granulocyte counts but had significantly higher serum urea and creatinine concentrations than those of survivor dogs at presentation (p<0.05). Serum cTn-I concentration level were positive in 11 of 14 non-survival dogs and negative in all of the survival dogs. The relative risk of death for the dogs with TNF-alpha positive was 3,39 times (95% CI:1,53-7,52) higher than that of dogs with TNF-alpha negative. This study demonstrates that leukocyte, lymphocyte, granulocyte, monocyte counts, serum urea and creatinine concentrations, cTn-I and TNF-alpha levels are useful parameters for predicting the prognosis of dogs with CPV.