期刊
NEUROCHEMISTRY INTERNATIONAL
卷 50, 期 1, 页码 5-11出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2006.08.005
关键词
systemic lupus erythematosus; animal models; brain; pathophysiology
Neuropsychiatric symptoms occur in systemic Jupus erythematosus (SLE), a complex, autoimmune disease of unknown origin. Although several pathogenic mechanisms have been suggested to play a significant role in the etiology of the disease, the exact underlying mechanisms still remain elusive. Several inbred strains of mice are used as models to study SLE, which exhibit a diversity of central nervous system (CNS) manifestations similar to that observed in patients. This review will attempt to give a brief overview of the CNS alterations observed in these models, including biochemical, structural and behavioral changes. (c) 2006 Elsevier Ltd. All rights reserved.
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