期刊
JOURNAL OF NEURAL TRANSMISSION
卷 114, 期 7, 页码 947-950出版社
SPRINGER WIEN
DOI: 10.1007/s00702-007-0632-9
关键词
frontotemporal dementia; parkinsonism; chromosome 17 (FTDP-17); P301S; race; tau mutation
In 9 patients with frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) with a P301S tau mutation, the predominant phenotype was frontotemporal dementia in 3 and parkinsonism in 6. Comparison of the tau genotype/haplotype carrying the mutation and the initial clinical sign showed association between H1/H1 and parkinsonism and between H1/H2 and personality change. Thus, the tau haplotype carrying the mutation and the tau genotype may be related to the clinical phenotype throughout the disease course.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据