期刊
NATURE METHODS
卷 4, 期 1, 页码 51-53出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH991
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资金
- NCI NIH HHS [CA-16042] Funding Source: Medline
- NIAID NIH HHS [AI-59095, AI-057870, AI-28697, 2-T32-AI-07323] Funding Source: Medline
Silencing induced by long terminal repeat (LTR)-encoded cis-acting response element, termed SILENCE, is a forward genetic system that allows for conditional, epigenetic control of host-gene transcription. This new research tool is independent of gene mutation or disruption, does not require complementation, and conditional gene repression appears complete at the level of protein function. SILENCE functions in hypodiploid cells and is a platform technology with broad applications in gene discovery. (c) 2007 Nature Publishing Group.
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