P matrix properties, injectivity, and stability in chemical reaction systems

In this paper we examine matrices which arise naturally as Jacobians in chemical dynamics. We are particularly interested in when these Jacobians are P matrices ( up to a sign change), ensuring certain bounds on their eigenvalues, precluding certain behavior such as multiple equilibria, and sometimes implying stability. We first explore reaction systems and derive results which provide a deep connection between system structure and the P matrix property. We then examine a class of systems consisting of reactions coupled to an external rate-dependent negative feedback process and characterize conditions which ensure that the P matrix property survives the negative feedback. The techniques presented are applied to examples published in the mathematical and biological literature.