期刊
IMMUNOBIOLOGY
卷 212, 期 6, 页码 521-533出版社
ELSEVIER GMBH
DOI: 10.1016/j.imbio.2007.03.011
关键词
Toll-like receptors; allergy
类别
Allergic diseases prevalence rates have increased dramatically over the last 50 years in developed countries and one explanation might be that modern practices in public health lead to a decreased exposure towards pathogens resulting in a misguided immune response. Recently, it has become evident that immune responses against pathogens are initiated by Toll-like receptors (TLRs) that recognize a variety of structures derived from viruses, bacteria, fungi or protozoa. In this review we will discuss TLR ligands, TLR signaling in regard to Th1 and Th2 immune responses, their involvement in the development and their therapeutic potential in treatment of allergic disease. (C) 2007 Elsevier GmbH. All rights reserved.
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