期刊
IMMUNOLOGIC RESEARCH
卷 37, 期 2, 页码 97-111出版社
HUMANA PRESS INC
DOI: 10.1007/BF02685893
关键词
gamma delta T cells; phosphoantigens; NK cell receptors; pattern-recognition receptors
类别
A numerically small subset of human T lymphocytes expresses a gamma delta T cell receptor (TCR). These gamma delta T cells share certain effector functions with ap T cells as well as with NK cells and NKT cells. The major peripheral blood 78 T cell subset in healthy adults expresses a V gamma 9V delta 2 TCR, which recognizes small phosphorylated metabolites referred to as phosphoantigens. V delta 1 gamma delta T cells mainly occur in the intestine. They recognize the stress-induced MICA/B and CD1c. Furthermore, gamma delta T cells express a variety of NK cell and pattern-recognition receptors which are responsible for the fine-tuning of effector functions. In recent years, gamma delta T cells start to emerge as a rewarding target for immunotherapeutic strategies against viral infections and cancer. A better understanding of factors that modulate gamma delta T cell function will further eluminate the potential of these cells.
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