期刊
CHEMICAL SOCIETY REVIEWS
卷 36, 期 8, 页码 1227-1238出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b617709c
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资金
- NIGMS NIH HHS [GM073500-02] Funding Source: Medline
The construction of homogeneous glycoproteins presents a formidable challenge to the synthetic chemist. Over the past few years there has been an explosion in the number of methods developed to address this problem. These methods include the development of novel ligation technologies for the synthesis of the protein backbone, as well chemical and enzymatic approaches for introducing complex glycans into the peptide backbone. This tutorial review discusses the application of these techniques to the synthesis of peptides and proteins possessing well defined glycans.
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