期刊
CANCER INVESTIGATION
卷 25, 期 6, 页码 405-410出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07357900701206349
关键词
breast cancer; immunohistochemistry; neurotrophins; predictive factors; TrkC
类别
Available data involve neurotrophins and their receptors in carcinomas. Quantitative evaluation of these molecules in these tumors might be useful as prognostic marker and eventual treatments. Our study on 40 mammary tumors tries to correlate expression of these molecules and prognosis. Immunohistochemistry for NGF, BDNF, NT3, TrkA, TrkB, TrkC, and p75 was used. Patient's age, histopathology, Bloom-Richardson grading, estrogen and progesterone receptors, Ki-67 index, HER-2, p53 were evaluated. Statistics found inverse relationship between grading and TrkC expression. We found significantly higher TrkC expression in Grade I than in Grade III tumors. Rise in TrkC expression could indicate good prognosis.
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