期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 294, 期 1-2, 页码 87-96出版社
SPRINGER
DOI: 10.1007/s11010-006-9248-x
关键词
exercise; treadmill training; cardiac hypertrophy; coronary artery occlusion
类别
资金
- NHLBI NIH HHS [P01 HL052490-140003, HL-52490, P01 HL052490, P01 HL052490-14] Funding Source: Medline
- NIA NIH HHS [K01 AG000875, K01 AG00875] Funding Source: Medline
Gradual occlusion (O) of the swine left circumflex coronary artery (LCX) with an ameroid occluder results in complete O within 3 weeks, collateral vessel development, and compensatory hypertrophy. The purpose of this investigation was to determine the independent and combined effects of O and exercise training (E) on gene expression in the swine heart. Adult Yucatan miniature swine were assigned to one of the following groups (n = 6-9/group): sedentary control (S), exercise-trained (E), sedentary swine subjected to LCX occlusion (SO), and exercise-trained swine with LCX occlusion (EO). Exercise consisted of progressive treadmill running conducted 5 d/wk for 16 weeks. Gene expression was studied in myocardium isolated from the collateral-dependent left ventricle free wall (LV) and the collateral-independent septum (SEP) by RNA blotting. E and O each stimulated cardiac hypertrophy independently (p < 0.001) with no interaction. O but not E increased atrial natriuretic factor expression in the LV, but not in the SEP. E decreased the expression of beta-myosin heavy chain in the LV, but not in the SEP. E retarded the expression of collagen III mRNA in SEP; but not in the LV. Exercise training and coronary artery occlusion each stimulate cardiac hypertrophy independently and induce different patterns of gene expression.
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