期刊
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
卷 26, 期 1, 页码 157-162出版社
WILEY
DOI: 10.1897/06-205R.1
关键词
Bacillus thuringiensis var. israelensis; detoxifying enzymes; insecticide sensitivities; mosquito populations; Ochlerotatus cataphylla
In the present Study, four Populations of the same held mosquito species, Ochlerotatus cataphylla, were sampled over the Rhone-Alpes region (France), and their respective sensitivity to the organophosphate temephos and the bacterio-insecticide Bacillus thuringiensis var. israelensis (Bti) was measured. The results obtained in toxicological tests showed significant differences in the larval sensitivities of the four populations for both insecticides. These differences appeared to be related to the activity of the three main families of detoxifying enzymes: Cytochrome P450 monooxygenases, glutathione-S-transferases (GSTs), and esterases. All three enzyme families were significantly overexpressed in the less susceptible larval population, and after multiple regressions, GSTs and esterases came out as the most explicative variables of the larval sensitivity. Considering these results and the chemical history of the sites in terms of insecticide treatments, the hypothesis of cross-effects of insecticides leading to resistance acquisition to Bti in field organisms emerges.
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