期刊
ANIMAL FEED SCIENCE AND TECHNOLOGY
卷 177, 期 1-2, 页码 108-115出版社
ELSEVIER
DOI: 10.1016/j.anifeedsci.2012.07.028
关键词
Montmorillonite-zinc oxide hybrid; Diarrhea; Intestinal microflora; Intestinal permeability; Intestinal morphology; Weanling pigs
资金
- National Natural Science Foundation of China [31072039]
- Zhejiang Provincial Natural Science Foundation [Z3100071]
- Ministry of Agriculture
- Fundamental Research Funds for the Central Universities
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1040]
Effects of montmorillonite-zinc oxide hybrid (MMT-ZnO) on performance, diarrhea, intestinal permeability and morphology were investigated. A total of 180 piglets (Duroc x Landrace x Yorkshire, average initial weight of 7.2 +/- 0.3 kg weaned at 27 +/- 1 d age) were randomly allotted to five groups for two weeks, each of which has six pens with six pigs per pen. The dietary treatments were: (1) basal control diet, 100 mg/kg of supplemental Zn as ZnSO4; (2) basal diet + 2.0 g/kg montmorillonite (MMT). equivalent to the MMT in the MMT-ZnO treatment; (3) basal diet + 500 mg/kg of Zn as ZnO; (4) basal diet + 500 mg/kg of Zn as MMT-ZnO; (5) basal diet + 2000 mg/kg of Zn as ZnO. The results showed that supplemental 500 mg/kg of Zn from MMT-ZnO or 2000 mg/kg of Zn from ZnO improved (P<0.05) average daily gain and daily feed intake, decreased (P<0.05) fecal scores at 7 and 14d postweaning, reduced (P<0.05) plasma D-lactate and diamine oxidase activity, improved (P<0.05) villus height and the villus height:crypt depth ratio at the jejunal mucosa as compared with the control, MMT or 500 mg/kg of Zn from ZnO. Pigs fed with 500 mg/kg of Zn as MMT-ZnO had lower (P<0.05) plasma levels of D-lactate than those fed with 2000 mg/kg of Zn as ZnO. Pigs fed with 500 mg/kg of Zn as MMT-ZnO had lower (P<0.05) number of intestinal Clostridium and Escherichia coli than those fed with the control. MMT or 500 mg/kg of Zn as ZnO. Supplementation with 2000 mg/kg of Zn as ZnO reduced (P<0.05) the number of Clostridium in proximal colon as compared with the control while had no (P>0.05) influence on intestinal E. coli. Supplemental MMT or 500 mg/kg of Zn from ZnO had no (P>0.05) effect on growth performance, intestinal microflora, permeability and morphology as compared to the control group. The results indicated that dietary addition of 500 mg/kg of Zn from MMT-ZnO was comparable to 2000 mg/kg of Zn from ZnO while more effective than MMT or 500 mg/kg of Zn from ZnO for enhancing growth performance, alleviating diarrhea, as well as improving intestinal microflora, mucosal barrier integrity and morphology of weaned pigs. (C) 2012 Elsevier B.V. All rights reserved.
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