期刊
JOURNAL OF CARBOHYDRATE CHEMISTRY
卷 26, 期 3, 页码 159-194出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07328300701351532
关键词
sialidase; trans-sialidase; sialylmimetic; carbasugars; N-acetylneuraminic acid; phosphonates
In an attempt to find competitive inhibitors of the trans- sialidase of the pathogen Trypanosoma cruzi, we have synthesized conjugates of carbocyclic sialylmimetics ( e. g., cyclohexenephosphonates) and galactose derivatives. A trans- sialidase inhibition assay revealed an interesting preference for ethylidene- spacered conjugates involving the 3- position of the sugar.
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