期刊
BIOFACTORS
卷 31, 期 3-4, 页码 165-169出版社
IOS PRESS
DOI: 10.1002/biof.5520310303
关键词
Apoptosis; BTB/POZ domain; Scleroderma; SPOP
资金
- Ministry of Health Welfare, Korea
- Discovery Program, Korea Engineering and Science Foundation, Korea
The proapoptotic function of SPOP protein was investigated in HeLa cells. HeLa cells underwent apoptosis by the overexpression of SPOP. Studies using SPOP deletion mutants suggest that BTB/POZ domain of SPOP protein is important for the induction of apoptosis in transfected cells. This study first proposes the proapoptotic aspect of the BTB/POZ domain of SPOP protein based on the finding that cells expressing the C-terminal fragment of SPOP containing the BTB/POZ domain underwent apoptosis.
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