期刊
AUTOPHAGY
卷 3, 期 1, 页码 17-20出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.3371
关键词
cytoplasm to vacuole targeting; lysosome; pexophagy; protein transport; vacuole; yeast
类别
Autophagy is a degradative pathway conserved among eukaryotes. It is a major route for degradation of long-lived proteins and entire organelles, such as peroxisomes. At926, a sterol glucosyltransferase, is specifically required for micro- and macropexophagy, but not for starvation-induced bulk autophagy in Pichia pastoris. Here we study the requirement of Sacchoromyces cerevisiae Atg26 in the Cvt pathway, nonspecific autophagy and pexophagy. Our results show that the S. cerevisiae atg26 Delta strain is not defective in prApe1 maturation, macroautophagy or peroxisome degradation, in contrast to the situation seen in Pichia pastoris. These studies highlight the importance of examining mutants in multiple organisms.
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