期刊
BIOMATERIALS
卷 28, 期 1, 页码 19-27出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2006.08.019
关键词
nitric oxide; biocompatibility; surface modification; cellulose; biosensor
资金
- NIBIB NIH HHS [EB000783, EB004527] Funding Source: Medline
- NICHD NIH HHS [R01 HD015434] Funding Source: Medline
Novel nitric oxide (NO) generating polymeric materials possessing immobilized organoselenium species are described. These materials mimic the capability of small organoselenium molecules as well as a known selenium-containing enzyme, glutathione peroxidase (GPx), by catalytically decomposing S-nitrosothiols (RSNO) into NO and the corresponding free thiol. Model polymeric materials, e.g., cellulose filter paper and polyethylenimine, are modified with an appropriate diselenide species covalently linked to the polymeric structures. Such organoselenium (RSe)-derivatized polymers are shown to generate NO from RSNO species in the presence of an appropriate thiol reducing agent (e.g., glutathione). The likely involvement of both immobilized selenol/selenolate and diselenide species for NO production is suggested via a catalytic pathway, as deduced in separate homogeneous solution phase experiments using nonimmobilized forms of small organodiselenide species. Preliminary experiments with the new RSe-polymers clearly demonstrate the ability of such materials to generate NO from RSNO species even after the contact with fresh animal plasma. It is anticipated that such NO generation from endogenous S-nitrosothiols in blood could render RSe-containing polymeric materials more thromboresistant when in contact with flowing blood, owing to NO's ability to inhibit platelet adhesion and activation. (c) 2006 Elsevier Ltd. All rights reserved.
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