期刊
IMMUNOLOGY AND CELL BIOLOGY
卷 85, 期 1, 页码 16-23出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.icb.7100009
关键词
cirrhosis; hepatitis B virus; immunology; immunopathogenesis; innate immunity; T-cells
Hepatitis B virus (HBV) infection is a non-cytopathic hepatotropic virus that can lead to severe liver disease including acute hepatitis, cirrhosis and hepatocellular carcinoma. Successful clearance of the virus as well as the establishment of liver disease is largely driven by a complex interaction between the virus and the host immune response. In this review, the immunological events, including both the innate and adaptive immune response are discussed in the setting of both acute and chronic HBV infection and liver disease.
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