期刊
GENOME BIOLOGY
卷 8, 期 10, 页码 -出版社
BMC
DOI: 10.1186/gb-2007-8-10-r219
关键词
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资金
- NHGRI NIH HHS [R01 HG002913] Funding Source: Medline
We develop an approach utilizing randomized genotypes to rigorously infer causal regulatory relationships among genes at the transcriptional level, based on experiments in which genotyping and expression profiling are performed. This approach can be used to build transcriptional regulatory networks and to identify putative regulators of genes. We apply the method to an experiment in yeast, in which genes known to be in the same processes and functions are recovered in the resulting transcriptional regulatory network.
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