期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 127, 期 1, 页码 39-46出版社
AMER SOC CLINICAL PATHOLOGY
DOI: 10.1309/7R6MU7R9YWJBY5V4
关键词
flow cytometry; precursor B-lymphoblastic leukemia/lymphoma; precursor B-ALL; immunophenotypic stability; minimal residual disease
类别
Essentially all cases of precursor B-lymphoblastic leukemia/dymphoma (B-ALL) demonstrate multiple immunophenotypic aberrancies relative to normal maturing B-cell precursors (hematogones). The stability of these aberrancies has relevance to follow-up minimal residual disease analysis. We compared the immunophenotypes at diagnosis and relapse in 51 childhood and adult B-ALLs with flow cytometry (FC) using broad antibody; panels. A total of 446 aberrancies were present at diagnosis (median, 9 per case; range, 2-14). All cases retained multiple aberrancies at relapse (median, 8 per case; range, 2-14). Antibody panels at relapse allowed assessment of 383 (85.9%) of the initial 446 aberrancies. Of these, 299 (78.1%)were persistent and 84 (21.9%) were lost at relapse. Overall, 73% of cases showed a loss of at least I aberrancy at relapse. However new aberrancies were detected in 60% of cases. These findings suggest that FC is suitable for the detection of residual B-ALL, provided that follow-up studies are not too narrowly targeted.
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