期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 5, 期 20, 页码 3330-3339出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b711112f
关键词
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By virtue of carefully chosen protecting groups, D-glucosamine trimethylene dithioacetal derivatives were successfully oxidized to the corresponding 6-aldehydes. This methodology reverses the donor and acceptor position on a normal open chain sugar and changes the relative position of the N-substituent. From the 6-aldehydes, heptose epoxide derivatives were prepared by a Corey-Chaykovsky reaction, and cyclized by the Corey-Seebach method. Depending on the designed protecting groups, the orthogonally protected six-and seven-membered ring amino carbasugars can be produced selectively and efficiently. (-)- Calystegine B-3 was synthesized from one of those products with high yield. This is the first anionic cyclization pathway to calystegine type structures.
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