期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 104, 期 1, 页码 365-370出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0609551104
关键词
blood flow; hemodynamics; ischemia; stroke; two photon
资金
- NCRR NIH HHS [RR/021907, R21 RR021907] Funding Source: Medline
- NIBIB NIH HHS [R01 EB003832, EB/003832] Funding Source: Medline
- NINDS NIH HHS [NS/043300, R01 NS043300] Funding Source: Medline
Penetrating arterioles bridge the mesh of communicating arterioles on the surface of cortex with the subsurface microvascular bed that feeds the underlying neural tissue. We tested the conjecture that penetrating arterioles, which are positioned to regulate the delivery of blood, are loci of severe ischemia in the event of occlusion. Focal photothrombosis was used to occlude single penetrating arterioles in rat parietal cortex, and the resultant changes in flow of red blood cells were measured with two-photon laser-scanning microscopy in individual subsurface microvessels that surround the occlusion. We observed that the average flow of red blood cells nearly stalls adjacent to the occlusion and remains within 30% of its baseline value in vessels as far as 10 branch points downstream from the occlusion. Preservation of average flow emerges 350 Am away; this length scale is consistent with the spatial distribution of penetrating arterioles. We conclude that penetrating arterioles are a bottleneck in the supply of blood to neocortex, at least to superficial layers.
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