期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
卷 144B, 期 1, 页码 20-26出版社
WILEY
DOI: 10.1002/ajmg.b.30374
关键词
glutamate receptor; major depression; polymorphism; kainate receptor; bipolar disorder
资金
- Intramural NIH HHS Funding Source: Medline
- NIMH NIH HHS [U01 MH46274, U01 MH46280, U01 MH46282, MH48969, MH00540, MH60866] Funding Source: Medline
The etiology of mood disorders remains elusive, despite our increasing understanding of the neurotransmitter systems and brain regions that are involved. We performed a large family-based association study to test if the human kainate receptor GluR7 gene (GRIK3) is associated with bipolar disorder (BP) or recurrent major depressive disorder (R-MDD). One hundred fifty-three multiplex BP families from the National Institute of Mental Health (NIMH) Genetics Initiative on Bipolar Disorder were analyzed with the transmission disequilibrium test (TDT). We detected a significant linkage disequilibrium (LD) indicated by preferential maternal transmission of the GluR7 S310 allele to R-MDD patients (P=0.012), but not to bipolar I disorder (BPI) patients (P=1.00). We performed a second independent study by applying the TDT in 81 parent-offspring triads from families that inherit recurrent early-onset major depressive disorder (RE-MDD). The results from this second study showed only a suggestive maternal association (P = 0.068). Our findings imply that the GluR7 gene is a susceptibility factor in R-MDD and that the glutamatergic receptor system plays a critical role in the disease etiology. (c) 2006 Wiley-Liss, Inc.
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