期刊
FEBS LETTERS
卷 581, 期 1, 页码 145-150出版社
WILEY
DOI: 10.1016/j.febslet.2006.12.009
关键词
cullin-5/VCAM-1; cul-5; rbx-2; cul-2; oogenesis
资金
- Grants-in-Aid for Scientific Research [19058012] Funding Source: KAKEN
Cul5-based complex is a member of ECS (Elongin B/ C-Cul2/Cul5-SOCS-box protein) ubiquitin ligase family. The cellular function of the Cul5-based complex is poorly understood. In this study, we found that oocyte septum formation and egg production did not occur in either cul-5- or rhx-2-depleted cul-2 homozygotes, although control cul-2 homozygotes laid approximately 50 eggs. These phenotypes are reminiscent of those caused by the MAP kinase mpk-1 depletion. In fact, activation of MPK-1 was significantly inhibited in cul-5-depleted cul-2 mutant and cul-2-depleted cul-5 mutant. Yeast two-hybrid analysis and RNAi-knockdown experiments suggest that oocyte maturation from pachytene exit and MPK-1 activation are redundantly controlled by the RBX-2-CUL-5- and RBX-1-CUL-2-based complexes. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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