期刊
JOURNAL OF NEUROSCIENCE
卷 27, 期 2, 页码 355-365出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3209-06.2006
关键词
WAVE-1; WRP; actin; Arp2/3; dendritic spine; synaptic plasticity
资金
- NIA NIH HHS [R01 AG020904, AG20904] Funding Source: Medline
- NIDDK NIH HHS [P01 DK044239, DK44239] Funding Source: Medline
- NINDS NIH HHS [R01 NS027037, NS27037, R01 NS017112, NS17112] Funding Source: Medline
The scaffolding protein WAVE-1 (Wiskott-Aldrich syndrome protein family member 1) directs signals from the GTPase Rac through the Arp2/3 complex to facilitate neuronal actin remodeling. The WAVE-associated GTPase activating protein called WRP is implicated in human mental retardation, and WAVE-1 knock-out mice have altered behavior. Neuronal time-lapse imaging, behavioral analyses, and electrophysiological recordings from genetically modified mice were used to show that WAVE-1 signaling complexes control aspects of neuronal morphogenesis and synaptic plasticity. Gene targeting experiments in mice demonstrate that WRP anchoring to WAVE-1 is a homeostatic mechanism that contributes to neuronal development and the fidelity of synaptic connectivity. This implies that signaling through WAVE-1 complexes is essential for neural plasticity and cognitive behavior.
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