期刊
CELL CYCLE
卷 6, 期 2, 页码 139-143出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.6.2.3788
关键词
HIPK2; p53; apoptosis; caspase; SUMO-1; Polycomb proteins; Ubc9; SUMO E3 ligase
类别
Homeodomain interacting protein kinase 2 (HIPK2) is an evolutionary conserved serine/threonine kinase that regulates gene expression by phosphorylation of transcription factors and accessory components of the transcription machinery. HIPK2 is activated in response to DNA-damaging agents or morphogenic signals and accordingly HIPK2-guided gene expression programs trigger differentiation and development or alternatively apoptosis. The kinase contributes to the regulation of remarkably diverse pathways such as p53 activation or Wnt signaling. Here we discuss recent findings from biochemical and functional experiments that allow a deeper understanding of the pleiotropic effects mediated by HIPK2.
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