期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 165, 期 2, 页码 164-174出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwk001
关键词
adiponectin; cardiovascular diseases; coronary disease; mortality
资金
- Medical Research Council [G106/1133] Funding Source: researchfish
- MRC [G106/1133] Funding Source: UKRI
- Medical Research Council [G106/1133] Funding Source: Medline
- NIA NIH HHS [AG07181, R01 AG007181-12, R37 AG007181, R01 AG007181] Funding Source: Medline
- NIDDK NIH HHS [R01 DK031801-15, R01 DK031801] Funding Source: Medline
Hypoadiponectinemia has been implicated in the development of obesity-related conditions, including dyslipidemia and coronary heart disease (CHD). In this study, the authors examined the association of adiponectin with CHD prevalence, incidence, and mortality among 1,513 community-dwelling men and women aged 50-91 years who were followed from 1984-1987 through 2004. In cross-sectional analyses, adiponectin concentrations were positively related to female sex, age, and high density lipoprotein cholesterol level and inversely related to waist girth, triglyceride level, and fasting plasma glucose level (all p's < 0.001). Adiponectin levels in the highest sex-specific quintile, as compared with the lowest, were associated with 44% decreased odds of prevalent CHD (p for trend = 0.03); adjustment for high density lipoprotein cholesterol and/or triglycerides eliminated this association. In 20-year prospective analyses, higher adiponectin concentrations predicted reduced risk of nonfatal myocardial infarction in men only; adiponectin was not associated with fatal incident CHD events or 20-year CHD mortality (n = 215 deaths) in either sex. Adiponectin levels in the highest sex-specific quintile, as compared with lower levels, were associated with almost 40% increased risks of cardiovascular disease death (n = 441) and death from all causes (n = 925), independent of age, sex, waist girth, lipid levels, and glucose level (both p's < 0.001). These results suggest that use of adiponectin for cardiovascular disease risk stratification is premature.
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