期刊
JOURNAL OF CELL BIOLOGY
卷 176, 期 2, 页码 173-182出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200607073
关键词
-
类别
资金
- NIGMS NIH HHS [GM030758, R01 GM030758, R01 GM059363, R01 GM059363-08, GM59363] Funding Source: Medline
How centrosome removal or perturbations of centrosomal proteins leads to G1 arrest in untransformed mammalian cells has been a mystery. We use microsurgery and laser ablation to remove the Centrosome from two types of normal human cells. First, we find that the cells assemble centrioles de novo after centrosome removal; thus, this phenomenon is not restricted to transformed cells. Second, normal cells can progress through G1 in its entirety without centrioles. Therefore, the Centrosome is not a necessary, integral part of the mechanisms that drive the cell cycle through G1 into S phase. Third, we provide evidence that centrosome loss is, functionally, a stress that can act additively with other stresses to arrest cells in G1 in a p38-dependent fashion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据