期刊
VACCINE
卷 25, 期 6, 页码 1149-1155出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2006.09.049
关键词
cholera vaccine; safety; immunogenicity
Vietnam currently produces an orally administered, bivalent (O1 and O139) killed whole-cell vaccine and is the only country in the world with endemic cholera to use an oral cholera vaccine in public health practice. In order to allow international use, the vaccine had to be reformulated to meet World Health Organization (WHO) requirements. We performed a randomized, placebo controlled, safety and immunogenicity studies of this reformulated vaccine among Vietnamese adults. One hundred and forty-four subjects received the two-dose regimen and 143 had two blood samples obtained for analysis. We found :hat this reformulated oral killed whole-cell cholera vaccine was safe, well tolerated and highly immunogenic. (c) 2006 Elsevier Ltd. All rights reserved.
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