期刊
JOURNAL OF NEUROSCIENCE
卷 27, 期 4, 页码 791-795出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4152-06.2007
关键词
rimonabant; dopamine; cocaine; nicotine; ethanol; cyclic voltammetry
资金
- NIDA NIH HHS [R01 DA010900, DA 10900] Funding Source: Medline
Transient surges of dopamine in the nucleus accumbens are associated with drug seeking. Using a voltammetric sensor with high temporal and spatial resolution, we demonstrate differences in the temporal profile of dopamine concentration transients caused by acute doses of nicotine, ethanol, and cocaine in the nucleus accumbens shell of freely moving rats. Despite differential release dynamics, all drug effects are uniformly inhibited by administration of rimonabant, a cannabinoid receptor (CB1) antagonist, suggesting that an increase in endocannabinoid tone facilitates the effects of commonly abused drugs on subsecond dopamine release. These time-resolved chemical measurements provide unique insight into the neurobiological effectiveness of rimonabant in treating addictive disorders.
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