期刊
CHEMICAL PHYSICS LETTERS
卷 434, 期 1-3, 页码 133-138出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cplett.2006.12.017
关键词
-
资金
- NIGMS NIH HHS [S06 GM008102, S06 GM008102-350088] Funding Source: Medline
The electronic properties of double strands composed of trimeric LNA, PNA, DNA and RNA single strands were investigated by density-functional molecular orbital calculations. The computed hybridization energies for the double strands involving PNA or LNA are larger than those for DNA-DNA and RNA-RNA. The larger stability is attributed to the presence of a larger positive charge of the hydrogen atoms contributing to the hydrogen bonds in the PNA-DNA and LNA-DNA double-strands. These results are comparable to the experimental finding that PNA and LNA single strands display high affinity toward a complementary DNA or RNA single strand. (c) 2006 Elsevier B.V. All rights reserved.
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